However, according to your page 'A high A/G ratio suggests underproduction of immunoglobulins as may be seen in some genetic deficiencies and in some leukemias. Unopposed counterregulatory hormone effect (glucagon & cortisol) causes further increases in glucose production from the liver and degradation of triglycerides. High total protein could be inflammatory, it's true, but my total protein isn't high. The A/G ratio can be decreased with short-term problems that cause inflammation, such as tissue trauma or infection. A low A/G ratio has been associated with many illnesses, which may be related to inflammation or certain cancer such as myeloma.
#High ag ratio free#
In addition to hyperglycemia, lack of insulin increases the degradation of triglycerides into free fatty acids in adipose tissue, which travel to the liver and are converted to the ketoacids: β-hydroxybutyric acid, acetone, and acetoacetate. An A/G ratio can be high or low due to abnormal changes to albumin levels, globulins, or both. Deprived of glucose utilization, the body must look elsewhere for "fuel" to survive. This is a common mechanism in diabetic ketoacidosis and a hyperosmolar hyperglycemic state. Lack of insulin also stimulates hyperglycemia by increasing hepatic gluconeogenesis. The protein, albumin, A/G ratio and globulin results of your blood work are a measure of the liver function and will be abnormal with liver damage as seen. Insulin deficiency causes a lack of glucose utilization in insulin-dependent tissues such as muscle and adipose, and therefore leads to hyperglycemia.
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